Applying the cross multiplication solves for.. meaning what's at the root of it, what does it do exactly?
Imagine you are in a spinning extra-vehicular harness in space (like George Clooney in the film Gravity). You have to fire your pneumatic boosters to counteract the spin. The reaction force from the gas jet is a vector, as is the radius arm from your centre of gravity to the gas jet. The cross-product of these two vectors tells you the magnitude and direction of the torque being supplied to counter your spin (or to increase your spin, or set you tumbling in a different direction, if you get it wrong)!
There are many more down-to-earth applications of the vector cross-product, often involving rotating objects.
… if you do not have all the variables for the matrix will it generally come down to a quadratic or similtaneous equation which is solved by a matrix?
I don’t understand what you are asking here. The matrix determinant form of the cross-product is just a way of remembering which components are multiplied by which in each direction!