You might notice here that 22 + 81 = 103, so I suspect that what is wanted is 103!/(22!*81!) which is nCr(103,22) (or nCr(103,81), which is the same). This can be calculated using the website calculator using the ncr function:
$${\left({\frac{{\mathtt{103}}{!}}{{\mathtt{22}}{!}{\mathtt{\,\times\,}}({\mathtt{103}}{\mathtt{\,-\,}}{\mathtt{22}}){!}}}\right)} = {\mathtt{15\,197\,882\,802\,514\,693\,962\,310}}$$
$${\left({\frac{{\mathtt{103}}{!}}{{\mathtt{81}}{!}{\mathtt{\,\times\,}}({\mathtt{103}}{\mathtt{\,-\,}}{\mathtt{81}}){!}}}\right)} = {\mathtt{15\,197\,882\,802\,514\,693\,962\,310}}$$
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